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Valter Longo and the Longevity Diet
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Valter Longo and the Longevity Diet

The USC researcher who proved fasting could regenerate the immune system

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Health.AI Editorial

March 28, 2026

9 min read
Valter Longo Fasting Mimicking Diet FMD ProLon

Valter Longo, director of the USC Longevity Institute, is the scientist who turned fasting into a clinically validated medical intervention.

The Fasting Mimicking Diet

Longo's signature contribution is the Fasting Mimicking Diet (FMD) — a 5-day program of carefully designed, low-calorie meals that trick the body into fasting while still providing some nutrition.

Clinical trials showed 3 cycles of FMD significantly reduced body weight, blood pressure, IGF-1, fasting glucose, inflammatory markers, and biological age.

The Longevity Diet Principles

Longo's daily eating pattern is based on research and centenarian populations:

Mostly plant-based — with small amounts of fish
Low protein until age 65 — then increase to prevent muscle loss
Time-restricted eating — eat within 11-12 hours per day
Periodic FMD cycles — 5-day FMD every 1-3 months
Nutrients from food, not supplements

His approach is distinguished by its emphasis on real-world evidence from long-lived populations.
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Medical Disclaimer — AI-Generated Content: This article was created with the assistance of artificial intelligence and is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. AI-generated content may contain errors or omissions. Always consult a qualified healthcare provider before making any health decisions. Read full disclaimer